Physiology and regulation of protein synthesis

Head : Grégory Boël

Team Publications


  1. Ousalem F, Singh S, Bailey NA, Wong KH, Zhu L, Neky MJ, Sibindi C, Fei J, Gonzalez RL, Boël G, Hunt JF (2023) Comparative genetic, biochemical, and biophysical analyses of the four E. coli ABCF paralogs support distinct functions related to mRNA translation bioRxiv. doi: 10.1101/2023.06.11.543863. Preprint.

  2. Fostier CR, Ousalem F, Leroy EC, Ngo S, Soufari H, Innis CA, Hashem Y, Boël G. (2023) “Regulation of the macrolide resistance ABC-F translation factor MsrD.” Nat Commun. 14(1):3891. doi: 10.1038/s41467-023-39553-8.

  3. Fostier CR, Monlezun L, Ousalem F, Singh S, Hunt JF, Boël G (2020) ABC-F translation factors: from antibiotic resistance to immune response. FEBS Lett. https://doi.org/10.1002/1873-3468.13984

  4. Boël G., Orelle C., Jault J.M., Dassa E. (2019) ABC systems: structural and functional variations on a common theme. Research Microbiol. 170:301-303. https://doi.org/10.1016/j.resmic.2019.10.006

  5. Ousalem F., Singh S., Chesneau O., Hunt J.F. and Boël G. (2019) ABC-F proteins in mRNA translation and antibiotic resistance, Research in Microbiology, 170:435-447. https://doi.org/10.1016/j.resmic.2019.09.005

  6. Boël G., Danot O., de Lorenzo V., Danchin A. (2019) Omnipresent Maxwell’s demons orchestrate information management in living cells. Microb Biotechnol. 12(2): 210–242. https://doi.org/10.1111/1751-7915.13378

  7. Lipońska A, Ousalem F, Aalberts DP, Hunt JF, Boël G. (2019) The new strategies to overcome challenges in protein production in bacteria. Microb Biotechnol.12(1): 44–47. https://doi.org/10.1111/1751-7915.13338

  8. Aalberts DP, Boël G, Hunt JF. (2017) Codon Clarity or Conundrum? Cell Syst. doi: 10.1016/j.cels.2017.01.004.

  9. Boël G., Letso R. Neely H., Price W.N., Wong K-H., Su M., Luff J., Valecha M., Everett J., Acton T, Xiao R., Montelione G.T., Aalberts D.P., and Hunt J.F. (2016) Codon influence on protein expression in E. coli correlates with mRNA level. Nature 529:358-363. doi: 10.1038/nature16509

  10. Boël G., Smith P.C., Ning W., Englander M.T., Chen B., Hashem Y., Testa A.J., Fischer J.J., Wieden H-J., Frank J., Gonzalez Jr. R.L., Hunt J.F. (2014) The ABC-F protein EttA gates ribosome entry into the translation elongation cycle. Nat.Struct. Mol. Bio. 21:143-151. doi: 10.1038/nsmb.2740

  11. Chen B., Boël G*., Hashem Y*., Ning W., Fei J., Wang W., Gonzalez Jr. R.L., Hunt J.F., Frank J. (2014) EttA binds to the ribosomal tRNA exit (E) site and regulates translation by restricting ribosome dynamics. (* Contributed equally) Nat. Struct. Mol. Bio., 21:152-159. doi: 10.1038/nsmb.2741

  12. Pancholi V, Boël G, Jin H. (2010) Streptococcus pyogenes Ser/Thr kinase-regulated cell wall hydrolase is a cell division plane-recognizing and chain-forming virulence factor. J Biol Chem. 285(40):30861-30874

  13. Mazé A*, Boël G*, Zúñiga M, Bourand A, Loux V, Yebra MJ, Monedero V, Correia K, Jacques N, Beaufils S, Poncet S, Joyet P, Milohanic E, Casarégola S, Auffray Y, Pérez-Martínez G, Gibrat JF, Zagorec M, Francke C, Hartke A, Deutscher J. (2010) Complete genome sequence of the probiotic Lactobacillus casei strain BL23. (* Contributed equally) J Bacteriol. 192:2647-2648.

  14. Boël G., Jin H., and Pancholi V. (2005) Inhibition of cell surface export of group A streptococcal anchorless surface dehydrogenase affects bacterial adherence and antiphagocytic properties. Infect. Immun. 73(10):6237-6248

  15. Maze A., Boël G., Poncet S., Mijakovic I., Le Breton Y., Benachour A., Monedero V., Deutscher J., Hartke A. (2004)The Lactobacillus casei ptsHI47T mutation causes overexpression of a LevR-regulated but RpoN-independent operon encoding a mannose class phosphotransferase system. J Bacteriol. 186:4543-4555.

  16. Boël G., Pichereau V., Mijakovic I., Mazé A., Poncet S., Gillet S., Giard J.C., Hartke A., Auffray A. and Deutscher J. (2004) Is 2-phosphoglycerate-dependent automodification of bacterial enolases implicated in their export? J. Mol. Biol. 337:485-496

  17. Mijakovic I., Sandrine P., Boël G., Mazé A., Gillet S., Jamet E., Decottignies P., Grangeasse C., Doublet P., Le Maréchal P. and Deutscher J. (2003) Transmembrane modulator-dependent bacterial tyrosine kinase activates UDP-glucose dehydrogenases., EMBO J. 22:4709-4718.

  18. Boël G., Mijakovic I., Mazé A., Poncet S., Taha M.K., Larribe M., Galinier A. and Deutscher J. (2003) Transcription regulators potentially controlled by HPr kinase/phosphorylase in Gram-negative bacteria. J. Mol. Microbiol. Biotechnol. 5:206-215